منابع مشابه
Porcine Circoviruses and Xenotransplantation
Allotransplantation and xenotransplantation may be associated with the transmission of pathogens from the donor to the recipient. Whereas in the case of allotransplantation the transmitted microorganisms and their pathogenic effect are well characterized, the possible influence of porcine microorganisms on humans is mostly unknown. Porcine circoviruses (PCVs) are common in pig breeds and they b...
متن کاملPorcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects
In the context of the shortage of organs and other tissues for use in human transplantation, xenotransplantation procedures with material taken from pigs have come under increased consideration. However, there are unclear consequences of the potential transmission of porcine pathogens to humans. Of particular concern are porcine endogenous retroviruses (PERVs). Three subtypes of PERV have been ...
متن کاملPorcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes
Type 1 diabetes is a disease that typically occurs in childhood and adolescence and has been estimated to account for 5% to 10% of all diagnosed cases of diabetes. It is caused by the destruction of beta cells in the islets of pancreas resulting in insulin deficiency that eventually leads to high glucose levels in the blood. If not properly treated, this condition can lead to long-term secondar...
متن کاملPorcine alanine transaminase after liver allo-and xenotransplantation.
Aspartate transaminase (AST) and alanine transaminase (ALT) are measured following liver transplantation as indicators of hepatocellular injury. During a series of orthotopic liver allo-and xenotransplants, we observed that there was an increase in AST in all cases. The anticipated concomitant rise in ALT did not occur when a wild-type (WT) pig was the source of the liver graft, but did occur w...
متن کاملPorcine endogenous retroviruses: an obstacle to cross during xenotransplantation
Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered as a major obstacle during xenotransplantati...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2017
ISSN: 1743-422X
DOI: 10.1186/s12985-017-0836-z